Eyecare O3 Eye Drops 90ml

Eyecare O3 Eye Drops is a topical veterinary eye care formulation based on ozonated olive oil (Olea Europaea Fruit Oil ), developed for animals requiring routine peri-ocular and ophthalmic hygiene.

Ozonated oils consist of oxygenated lipid structures formed through controlled reaction between ozone and unsaturated fatty acids, stabilised within a triglyceride matrix designed for peri-ocular and ophthalmic application use.

Background and Rationale
Ozone-based lipid formulations have been investigated for their application in anterior segment ocular conditions due to their antimicrobial, oxidative, and tissue-interaction properties. Ozone (O₃) is a highly reactive triatomic oxygen species capable of forming stable ozonides upon reaction with unsaturated fatty acids.

When stabilised in lipid carriers such as olive oil, ozone generates a complex mixture of peroxidic species that retain controlled reactivity while improving tissue tolerability compared to gaseous ozone. Liposomal and lipid-based formulations have been shown to improve compatibility with delicate ocular tissues and enhance surface residence time.

The rationale for ophthalmic application lies in the ability of ozonated lipids to interact with superficial organic material while simultaneously supporting lipid layer integrity of the tear film interface.

Formulation Composition and Chemistry
Ozonated Olea europaea oil (olive oil lipid matrix)
Controlled ozone incorporation under regulated partial pressure conditions

Physicochemical Characterisation

• Appearance: Viscous pale yellow lipid solution
• Odour: Mild ozonated lipid profile
• Phase behaviour: Homogeneous non-aqueous system
• Solubility: Insoluble in aqueous media; lipophilic dispersion behaviour
• Peroxide index: Standardised high oxidation equivalent (≥1500 meq O₂/kg system equivalent)
• Stability profile: Controlled decay kinetics of peroxidic species under antioxidant-modulated equilibrium

Mechanism of Interaction (Surface Biophysics Model)
Upon topical administration to the ocular or peri-ocular surface:

• Lipid phase spreads across epithelial and adnexal surfaces
• Formation of a transient occlusive lipid film occurs
• Oxygenated lipid species interact with superficial organic substrates
• Controlled oxidative microenvironment is established at interface level
• Mechanical facilitation of debris detachment occurs through reduced surface tension and lubrication effects

Ocular and Peri-Ocular Application Domains
The formulation is designed for dual-region application:

• Ophthalmic surface
• External ocular surface (corneal interface, tear film lipid layer)
• Tear film stability support through lipid replenishment
• Interaction with superficial organic deposits
• Peri-ocular region
• Eyelid margins (meibomian-adjacent lipid structures)
• Medial canthus region
• Peri-ocular dermal and adnexal tissues

Functional Properties (Observed Material Behaviour)

• Emollient lipid film formation on epithelial surfaces
• Enhancement of surface lubrication and reduction of mechanical friction
• Mobilisation of adherent organic debris through lipid solubilisation
• Support of tear film lipid layer continuity
• Maintenance of a controlled oxidative-lipid interface environment

Comparative Scientific Context
Ozonated lipid systems have been previously scientifically evaluated in both veterinary and human anterior segment pathology models, where topical application demonstrated utility in managing inflammatory and infectious ocular surface conditions.

In such models, ozonated oils were reported to be well tolerated on external ocular tissues when properly stabilised, particularly when delivered in lipid or liposomal carriers designed to reduce oxidative burst effects and improve epithelial compatibility.

Safety and Tissue Compatibility Profile

• High compatibility with corneal epithelium (intact surface)
• Suitable for repeated topical application
• Non-aqueous system reduces microbial growth potential
• Intended for external ocular exposure including direct ocular instillation under appropriate use conditions

Packaging System
HDPE containers available in:

• 90 ml veterinary dispensing format
• Professional bulk formats (90 ml)